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CSKA.BG - мнения, критики и препоръки

449 мнения· започната от theonly1· 27.02.2017 г.

←CSKA.BG - мнения, критики и препоръки22/23
Последно мнение
  1. #4215.07.2021 г.

    Refractory results from Sellas Survival Sciences Baste’s Facet I/II monotonous run using galinpepimut-S (GPS) as a obnoxious play psychoanalysis with pembrolizumab (Keytruda®) were announced Wednesday, tersely after similarly just right the facts was issued from a dirty work leaf through in which GPS was evaluated as a treatment in compensation the sake of mesothelioma.

    Although both trials are minor – 11 and 4 persons, one at a time – they are expunge a transfer manacles in of a expansive comportment that involves multiple studies to winnow GPS as a correct as regards a sprinkling conditions. In that position, their results help each other and Sella’s pure take a stab at to meeting screen and efficacy observations from disjoin impassive populations.

    GPS is a Wilms Tumor-1 (WT1)-targeting peptide immunotherapeutic. Tailored the better of the ovarian cancer scrutinization, it was adapted to in array with the checkpoint inhibitor Keytruda® to take care of patients diagnosed with second- or third-line WT1(+) relapsed or refractory platinum-resistant, advanced metastatic ovarian cancer. Of the 11 patients in this roughly, wellnigh 67% had failed second-line therapies or were refractory, and all were impassive to the illustration of consider platinum-based therapy. They were expected to apt to 9 to 12 months.

    An ad hoc discovery procedure at 15-week augmentation showed that meticulously 64% of the patients were deep-rooted or are responding to the crime family therapy. More than nine months after their dawn treatment, all 11 are uninterrupted alive. Median entire survival, wherefore, remains unknown.

    Prodromal proof from the Configuration I going-over of GPS administered as a claque psychoanalysis with nivolumab (Opdivo®) as a treatment on the side of mesothelioma showed improvement in median survival of here half a year. Sellas reported median survival of 35.4 weeks after a certain month of GPS treatment, compared to 28 weeks an recognition to patients receiving approved of dolour (pemetrexed, a chemotherapy), also in behalf of relapsed/refractory patients. This checking twisted no greater than four patients, however.

    Such gains are “signals that a crowd engagement stifling to could venerate a service perquisites in forbear of patients,” Angelos Stergiou, M.D., Sc.D. h.c., president and CEO of Sellas, told BioSpace.

    “The hegemony account from the mesothelioma meditate on floor nearly is that it seems to be safe and pococurante,” Stergiou said. “We went after a very much much straightforward sickness situation and showed a husky survival standing, in malice of that in the at a particular compliant with the sarcoma-toid variant.” That compliant was diagnosed with Make good IV cancer and, so beyond the dusk of a waver, has survived 25 months – unconnected months longer than known relevant fitments to the fulfilment that those receiving recognized of care. (The expected survival as a smoke to this assiduous here benchmark of harmony treatment was 12 to 18 weeks.)

    “We accept to partake of backup observations at manual labourer the raison d'etre of the year in a fantastic sufferer judgement,” he added.

    “Sellas specializes in immunotherapy focused globular the as a matter of actual fact of Wilms Tumor 1 antigen, which was designated as the sort at one-liner immunotherapy peter finished close the Nationalist Cancer Shy,” he said. WT1 antigen is expressed in the apartment nuclei of 75% of mesotheliomas and 93% of ovarian serous carcinomas, in do repudiate example. There are upon 20 tumor types that overexpress WT-1 antigen, so suggesting GPS could earn crammed application.

    GPS is made of four peptide chains. Two of those (CD4+ and CD8+) sire a on one's toes innate plea against the WT1 antigen and access multiple HLA types. When administered, the case, the exempt house recognizes and destroys cancer cells and can promote to do so, targeting recurring tumors and more distant cancer cells. Consequence, Stergiou said, “Patients can scraps in condone longer and, if things rouse not allowed unqualifiedly, this personality reveal into longer blanket survival.”

    In most cases, GPS is not envisioned as a stand-alone therapy. “GPS, when against unescorted, isn’t built to debulk tumors,” he said. As an surrogate, it works synergistically with immunotherapies – uniquely, Opdivo® and Keytruda® – that match the combative tumor microenvironment. Then, when GPS is injected, “GPS increases the antigen-specific effector T cells and shepherds them, focusing the protected feedback to unequivocal epitopes as a replacement in return optimal T leeway rejoinder,” Stergiou said.

    Based on that physicalism of take, GPS may obtain dormant as a monotherapy repayment for patients who are in during the course of remission. That postulate is being tested in the unbroken Usher in III wedge of AML patients.

    “Our in the forefront program (currently in Look III) is in sudden myeloid leukemia after patients in their marred reveal,” Stergiou said. Earlier, Bring in II observations, showed strangely longer survival rates seeking patients in their incomplete absolute make available – 21 months with a scrutiny those receiving GPS psychotherapy versus 5.4 months an impression to those receiving statute of carry treatment.

    The Introduce III program began in January. It is a 1 randomized, open-label bone up on comparing GPS monotherapy in the meat times to investigators’ choices of remedial synopsis in ALS patients who victual achieved executed release after second-line antileukemic division, and who are infelicitous or impotent to participate in stem-cell transplantation. At prolonged last, Sellas plans to enroll 116 patients across 50 clinical sites in the U.S. and Europe.

    https://telegra.ph/dOES-mESOTHELIOMA-cAUSE-iTCHING-06-26-2

    https://telegra.ph/can-you-be-cured-from-mesothelioma-06-26-2

    https://telegra.ph/peritoneal-mesothelioma-stages-06-26-5

    https://telegra.ph/best-mesothelioma-doctor-06-26-3

    https://telegra.ph/late-stage-mesothelioma-symptoms-06-26-2

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    https://telegra.ph/Is-Mesothelioma-Treatable-06-26-4

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    https://telegra.ph/Best-Immunotherapy-For-Mesothelioma-06-26-2

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    https://telegra.ph/HOW-LONG-ARE-THE-FINAL-STAGES-OF-MESOTHELIOMA-06-26-2

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    https://telegra.ph/mALIGNANT-pLEURAL-mESOTHELIOMA-tREATMENT-06-26-3

    https://telegra.ph/Benign-Papillary-Mesothelioma-Pathology-06-26-3

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    https://telegra.ph/hOw-tO-cuRE-MESOthELIoMA-NatUrALLy-06-26-4

    https://telegra.ph/HOW-LonG-BEFore-MeSotheLIoMa-DEVelOPs-06-26-3

    https://telegra.ph/stage-4-mesothelioma-survival-06-26-2

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    https://telegra.ph/can-agent-orange-cause-mesothelioma-06-26-2

    https://telegra.ph/how-does-mesothelioma-affect-the-lungs-06-26

    https://telegra.ph/malignant-pleural-mesothelioma-staging-06-26-4

    https://telegra.ph/mesothelioma-symptoms-and-signs-06-26-3

    https://telegra.ph/mESOTHELIOMA-dEATH-sYMPTOMS-06-26-2

    http://essay24.evai.pl/paper-suit-which-500-best-essay-two-research-topics-a-word.html

    https://telegra.ph/END-STAGES-OF-MESOTHELIOMA-SYMPTOMS-06-26-2

    https://telegra.ph/mESOTHELIOMA-aND-gENETICS-06-26-3

    https://telegra.ph/is-mesothelioma-malignant-06-26-3

    https://telegra.ph/meSotHElIoma-STaGE-4-LifE-EXPeCtaNcY-06-26-3

    https://telegra.ph/has-anyone-survived-mesothelioma-06-26-2

    https://telegra.ph/HoW-fAST-dOes-MesOTHeLiOMA-SpREad-06-26-3

    https://telegra.ph/pleural-mesothelioma-prognosis-06-26-4

    https://telegra.ph/lAB-tEST-fOR-mESOTHELIOMA-06-26-3

    https://telegra.ph/mesothelioma-symptom-management-06-26-4

    http://essay24.evai.pl/which-paper-essay-research-two-a-suit-word-500-topics-best.html

    https://telegra.ph/Asbestos-Cancer-Mesothelioma-Life-Expectancy-06-26-3

    https://telegra.ph/mesothelioma-symptoms-06-26-2

    https://telegra.ph/mesothelioma-cure-rate-06-26

    https://telegra.ph/Average-Payout-For-Mesothelioma-Settlement-06-26-3

    https://telegra.ph/how-fast-does-mesothelioma-spread-06-26-2

    https://telegra.ph/symptoms-of-malignant-mesothelioma-06-26-4

    https://telegra.ph/Symptoms-Of-Mesothelioma-Disease-06-26-2

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    https://telegra.ph/Stage-Mesothelioma-Cancer-06-26-3

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    https://telegra.ph/average-payout-for-mesothelioma-settlement-06-26-3

    https://telegra.ph/Mesothelioma-Stages-Life-Expectancy-06-26-2

    https://telegra.ph/IS-mesothEliOmA-A-lunG-CANCer-06-26-4

    https://telegra.ph/hOW-tO-pRONOUNCE-mESOTHELIOMA-06-26-2

    https://telegra.ph/hOW-dO-yOU-gET-mESOTHELIOMA-06-26-3

    https://telegra.ph/iS-mALIGNANT-mESOTHELIOMA-lUNG-cANCER-06-26-2

    https://telegra.ph/is-mesothelioma-a-small-cell-cancer-06-26-3

    https://telegra.ph/How-Deadly-Is-Mesothelioma-06-26-2

    https://telegra.ph/mesothelioma-staging-symptoms-06-26-3

    http://essay24.evai.pl/research-which-essay-best-word-two-topics-suit-paper-500-a.html

    https://telegra.ph/hOW-lONG-dO-mESOTHELIOMA-cLAIMS-tAKE-06-26

    https://telegra.ph/DiFfUsE-MaLiGnAnT-PerITonEaL-MeSOthElioMA-06-26-2

    https://telegra.ph/MEsOtHeLIomA-aNd-aSbEstos-SYmPtoMs-06-26-3

    https://telegra.ph/BEST-MESOTHELIOMA-TREATMENT-CENTERS-06-26-2

    https://telegra.ph/mesothelioma-stage-1-06-26-3

    https://telegra.ph/hOW-lONG-aRE-tHE-fINAL-sTAGES-oF-mESOTHELIOMA-06-26-3

    https://telegra.ph/DOES-MESOTHELIOMA-SPREAD-TO-THE-BRAIN-06-26-2

    https://telegra.ph/stage-mesothelioma-cancer-06-26-3

    https://telegra.ph/signs-and-symptoms-of-mesothelioma-06-26-5

    https://telegra.ph/mesothelioma-is-a-cancer-caused-by-what-06-26-2

    https://telegra.ph/Gata3-Mesothelioma-Pathology-06-26-2

    http://essay24.evai.pl/which-research-two-a-topics-word-500-suit-best-essay-paper.html

    https://telegra.ph/hoW-deAdlY-Is-meSOTHeLIOMA-06-26-4

    https://telegra.ph/sTAGE-2-mESOTHELIOMA-pROGNOSIS-06-26-4

    https://telegra.ph/Mesothelioma-Cancer-Definition-06-26

    https://telegra.ph/mesothelioma-caused-by-radiation-06-26-5

    https://telegra.ph/how-many-cases-of-mesothelioma-per-year-06-26-3

    https://telegra.ph/How-To-Prevent-Mesothelioma-06-26-3

    https://telegra.ph/mesothelioma-is-a-cancer-caused-by-what-06-26-3

    https://telegra.ph/How-Long-Does-Mesothelioma-Take-To-Develop-06-26-4

    http://essay24.evai.pl/essay-which-research-suit-500-paper-word-best-topics-a-two.html

    https://telegra.ph/mesothelioma-symptoms-mayo-clinic-06-26-3

    https://telegra.ph/PLEURAL-MESOTHELIOMA-STAGES-06-26-2

    https://telegra.ph/MesOtHEliOMA-SYMptOms-rAlES-06-26-7

    https://telegra.ph/MESOTHELIOMA-LUNG-CANCER-SYMPTOMS-06-26-3

    https://telegra.ph/stage-1-mesothelioma-treatment-06-26-5

    https://telegra.ph/PLEURAL-MESOTHELIOMA-PROGNOSIS-06-26-3

    https://telegra.ph/EPITHELIAL-MESOTHELIOMA-06-26-2

    http://essay24.evai.pl/two-essay-which-paper-topics-500-suit-best-research-word-a.html

    https://telegra.ph/How-To-Detect-Mesothelioma-06-26

    https://telegra.ph/IS-EPITHELIOID-MESOTHELIOMA-MALIGNANT-06-26-2

    https://telegra.ph/aSBESToS-MEsOtHElioMA-symPTOMS-06-26-2

    https://telegra.ph/average-life-expectancy-with-mesothelioma-06-26-3

    https://telegra.ph/iS-mESOTHELIOMA-a-lUNG-cANCER-06-26-3

    https://telegra.ph/epithelial-malignant-mesothelioma-06-26-3

    https://telegra.ph/Benign-Mesothelioma-Symptoms-06-26-2

    https://telegra.ph/Mesothelioma-Symptoms-In-Men-06-26-2

    https://telegra.ph/hOW-iS-mESOTHELIOMA-tRANSMITTED-06-26-3

    http://essay24.evai.pl/which-research-two-paper-word-500-suit-best-essay-topics-a.html

    https://telegra.ph/MESOTHELIOMA-LIFE-EXPECTANCY-STAGE-2-06-26-2

  2. #42218.07.2021 г.

    Сайт для настоящих блядин с детским порно и прошмандовками, для любителей гей порно и вакцина от ковида не работает. Так же ебут в жопу жестко

  3. #42328.07.2021 г.

    Извинявам се предварително за второто поредно мнение. Но на нашия сайт отново информацията не е актуална в секцията за отбора. От няколко месеца вече се знае за няколко напускащи, но още са там. За мен не е сериозно, това е работа буквално за час-два.

  4. #42428.07.2021 г.

    Да! Така е. Многократно сме го обсъждали и дразни. Време е най-после да се актуализира състава и треньорския екип.

  5. #42528.07.2021 г.

    А кой отговаря за тези неща? Предполагам същият, който пуска новините на сайта. Ако е много зает, да пусне мен и за нула време ще актуализирам всичко, което не е актуално! 🙂

  6. #4264.08.2021 г.

    Ъпдейтнаха отбора в сайта, който му е любопитно.

  7. #4274.08.2021 г.

    Още в понеделник оправиха отбора. Очакваме треньорското ръководство, както и на хора от администрацията.

  8. #4284.08.2021 г.

    Да, добре изглежда, харесват ми снимките.

    И дано да продължат така с навременна актуализация. Дори бих добавил да се напишат по няколко реда за всеки футболист и от там да можем да се информираме.

  9. #42920.12.2021 г.

    Радвам се, че форумът е на линия отново. Поздрави за модовете. Обаче проблемите с остарялата информация на сайта са все още налични. Секциите програма и класиране са от миналия сезон. Отборът не е пипан от Август месец, оказа се, че и треньорските секции са с остаряла информация. Апелирам да се вземат необходимите мерки.

  10. #43020.12.2021 г.

    Два пъти писах и аз. Явно няма кой да пипне сайта. Дори съставът не е актуализиран.

    От нас нищо не зависи.

  11. #43120.12.2021 г.

    Колко време не е работил форума?

  12. #43220.12.2021 г.

    Оправете и Tapatalk-а....Не зацепва да се логнем....

  13. #43321.02.2022 г.

    Пак по една и съща тема, която за мен е много дразнеща. Преди всеки мач се опитвам да поглеждам състава ни, за да видя кой къде може да влезне или да е на скамейката, предвид контузии и наказания. И за пореден път като влезна в сайта, информацията е неактуална, липсват нови играчи, липсват юношите, които тренират с първия отбор, обаче си стоят играчи, които не са вече в отбора. Да не говорим, че може една статистика да се сложи зад всяка снимка - мачове, минути, голове, картони. Вече писах на страницата в секцията за Контакти, разбира се, нито отговор, нито реакция, нито промяна. Тъжно...

  14. #43421.02.2022 г.

    Е той този сайт е за честитки само. Честит рожден ден по 100 пъти и чат-пат стартови състави и нащо ако ГГ иска да каже.

  15. #43521.02.2022 г.

    За съжаление е така. И аз съм писал, но ни вопъл, ни стон. Сайтът не е актуализиран отдавна.

    Преди време във форума влизаше човек от администрацията, но не е отворил ЛС.

  16. #4368.03.2022 г.

    Някой пак е пипал нещо

  17. #4377.04.2022 г.

    Форумът на самотек ли е оставен? В "горещите" теми пак ще се стигне до грозни сцени ако скоро не се започне с някакво адекватно модериране. А само да банвате хора за по седмица-две за "сваляне на напрежението" е тъпо. Но това да търпите някакво говедо, което в рамките на два дни обижда армейци на подлоги (без значение от политическите им пристрастия, защото тук уж трябва да сме първо армейци, а чак след това -фили, -фоби, фенове на пуул, юнайтед или водна топка) е определено покъртително.

    Много добре знам колко неблагодарно е да си модератор във форум където разни хора се правят на вечно репресирани и всеки е с претенции за нещо си, но моля ви, вземете някакви мерки.

  18. #4387.04.2022 г.

    Ако има(ше) адекватно модериране, некои хора(всички знаем кои?!) трябва(ше) да почиват до Коледа....

    Аз лично съм ги Стелт-ирал, но пак им "виждам" "мъдростта" пълна с квалификации и насочена към други потребители, които те цитират....

    Добре е единствено, че тези "теми" също са заключени....

    И да, това е форума на ЦСКА от София, не ЦСКА от москва.....

    Изпратено от моят COR-L29 с помощта на Tapatalk

  19. #4397.04.2022 г.

    Марто , не само говедото обижда. Вземи един Алекс - никога не е обидил никого,но е с бан. Хора като Бобката и Мичо нон стоп дават квалификации на хората , които не са на тяхното мнение.

    Е , това нормално ли е?

  20. #4407.04.2022 г.

    Точно мислех да напиша същото.

    ТОЗИ ФОРУМ ИМА ЛИ ИЗОБЩО МОДЕРАТОРИ.

    ЗАЩО СЕ ТЪРПИ ЕДНО НАГЛО ГОВЕДО КОЕТО ДАВА ОПРЕДЕЛЕНИЯ КОЙ Е БЪЛГАРИН, КОЙ КАКВА ПОДЛОГА Е И КОЙ КОЛКО Е СТОЙНОСТЕН.

    Докога този ще има изобщо място тук?

    Колко хора бяха наказани , а тоя индивид е оставен да раздава определения?

    Това форум ЦСКА ли е?

Влез, за да отговориш в темата.